Highlights: ? Health information technology (HIT) is shown to benefit quality of care for HIV/AIDS patients. ? An easy-to-use system responsive to users’ needs effectively facilitates rigorous application of quality improvement methods. ? HIT can lead to improved health outcomes for HIV/AIDS patients.Abstract: Purpose: This paper presents research on the interplay of health information technology (HIT), quality improvement and progression of health status. The purpose of the research was to determine whether electronic exchange of health information impacts quality of care and, by extension, health outcomes of patients with HIV/AIDS. The research was supported as a demonstration project under the Information Technology Networks of Care Initiative sponsored by the U.S. Health Resour….