Conclusions: This study shows that although TA showed a slightly better effectiveness, there is no significant difference between the performance of the CW and the TA methods in terms of number of usability problems identified and the mean severity of these problems. Since no single evaluation method will uncover all of the usability problems a combination of methods is advised as the most appropriate approach, especially if usability problems can lead to potentially fatal outcomes. (Source: International Journal of Medical Informatics).