Highlights: ? Nurses saved time using the integrated electronic drug monitoring system (eDMS). ? Nurses’ perceived the eDMS to be safer, simpler and more standardised. ? Time saved by nurses enabled them to undertake more nurse-led clinics. ? First study to quantify time saved by nurses using an integrated eDMS.Abstract: Objective: To evaluate the impact of an electronic drug monitoring system (eDMS) for ambulatory rheumatology patients on time nurses spent on, and the process of, drug monitoring.Methods: The study was conducted in the Rheumatology Department of a large metropolitan hospital. The eDMS, a module of the Hospital Clinical Information System (HCIS), was designed to allow electronic ordering and subsequent monitoring of ambulatory patients on long-term, immunosuppress….