Highlights: ? Knowledge and attitude were not predictive of perceived usefulness or perceived ease of use among health workers in Nigeria. ? Endemic barriers to technology are an important addition to the TAM in low-resource settings. ? End-user preference should be considered in ICT implementation strategies in developing countries.Abstract: Purpose: To investigate the potential of information and communication technology (ICT) adoption among maternal and child health workers in rural Nigeria.Methods: A prospective, quantitative survey design was used to collect data from quasi-randomly selected clusters of 25 rural health facilities in 5 of the 36 states in Nigeria over a 2-month period from June to July 2010. A total of 200 maternal and child health workers were included in the su….