Highlights: ? Introduction of CPOE improved pharmacy turnaround times. ? Despite improved pharmacy turnaround, there was no change in the time to the first dose of antibiotics. ? Admission workflow is a complex process, and will require a multifaceted approach in order to further improve antibiotic administration time in the neonatal intensive care unit.Abstract: Objective: The study objective was to determine if computerized provider order entry (CPOE) systems impaired or enhanced workflow in the neonatal intensive care unit (NICU) by comparing the timing of administration of the first dose of antibiotics before and after CPOE system implementation.Methods: We conducted a pre-post intervention comparative study of the length of time between admission and administration of initial an….