This study evaluated BHIS uptake by health care workers, and pre and post BHIS deployment mortality in selected areas and public health care expenditures.Methods: BHIS encounter data were compared to encounter data from required Ministry of Health reports from licensed health care entities. De-identified vital statistics death data for the eight BHIS protocol disease domains and three non-protocol domains were compared from 2005 to 2011. Belize population data came from the Statistical Institute of Belize (2005–2009) and from Belize census (2010) and estimate (2011). Public health system expenditures were compared by fiscal years (2000–2012).Results: BHIS captured over 90{ca7ad0b74511a57bb2016f24c729dd7716d5352e92d2275aa1f91fb22c36b0a7} healthcare encounters by year one, 95{ca7ad0b74511a57bb2016f24c729dd7716d5352e92d2275aa1f91fb22c36b0a7} by year two. Mortality rates decreased in the eight BHIS protocol domains (….