Abstract: Assisted Living provides a long-term care option that combines supportive systems and services for monitoring and assessing the health status with activities of daily living and health care. Daily monitoring of the health status in subjects characterized by chronic and/or degenerative conditions is not possible in all those cases where the disease progression has to be evaluated only by a direct interaction between the patients and the healthcare structures on a regular basis, over time and for life. In this respect, this work proposes an evolutionary-fuzzy decision support system (DSS) for assessing the health status of subjects affected by multiple sclerosis (MS) during the disease progression over time. Such a DSS has been defined and implemented exploiting a novel approach de….